UFC Fight Night 281: du Plessis vs. Usman was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on July 18, 2026, at the Paycom Center in Oklahoma City, Oklahoma, United States. A middleweight bout between former UFC Middleweight Champion (also former KSW Welterweight Champion) Dricus du Plessis and former UFC Welterweight Champion (also The Ultimate Fighter: American Top Team vs. Blackzilians welterweight winner) Kamaru Usman headlined the event.